SFR Santé Lyon-Est: ALECS Module SPF: Bibliographie

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Liste des Publications liées aux activités d'ALECS

2019

ERRα promotes breast cancer cell dissemination to bone by increasing RANK expression in primary breast tumors.
Vargas G, Bouchet M, Bouazza L, Reboul P, Boyault C, Gervais M, Kan C, Benetollo C, Brevet M, Croset M, Mazel M, Cayrefourcq L, Geraci S, Vacher S, Pantano F, Filipits M, Driouch K, Bieche I, Gnant M, Jacot W, Aubin JE, Duterque-Coquillaud M, Alix-Panabières C, Clézardin P, Bonnelye E. Oncogene. 2019 Feb;38(7):950-964. doi: 10.1038/s41388-018-0579-3. Epub 2018 Nov 26.

2018

TMPRSS2:ERG gene fusion expression regulates bone markers and enhances the osteoblastic phenotype of prostate cancer bone metastases. Delliaux C, Tian TV, Bouchet M, Fradet A, Vanpouille N, Flourens A, Deplus R, Villers A, Leroy X, Clézardin P, de Launoit Y, Bonnelye E, Duterque-Coquillaud M. Cancer Lett. 2018 Dec 1;438:32-43. doi: 10.1016/j.canlet.2018.08.027. Epub 2018 Sep 7.

miRNA-30 Family Members Inhibit Breast Cancer Invasion, Osteomimicry, and Bone Destruction by Directly Targeting Multiple Bone Metastasis-Associated Genes. Croset M, Pantano F, Kan CWS, Bonnelye E, Descotes F, Alix-Panabières C, Lecellier CH, Bachelier R, Allioli N, Hong SS, Bartkowiak K, Pantel K, Clézardin P. Cancer Res. 2018 Sep 15;78(18):5259-5273. doi: 10.1158/0008-5472.CAN-17-3058. Epub 2018 Jul 24.

The C-Terminal Intact Forms of Periostin (iPTN) Are Surrogate Markers for Osteolytic Lesions in Experimental Breast Cancer Bone Metastasis. Gineyts E, Bonnet N, Bertholon C, Millet M, Pagnon-Minot A, Borel O, Geraci S, Bonnelye E, Croset M, Suhail A, Truica C, Lamparella N, Leitzel K, Hartmann D, Chapurlat R, Lipton A, Garnero P, Ferrari S, Clézardin P, Rousseau JC. Calcif Tissue Int. 2018 Nov;103(5):567-580. doi: 10.1007/s00223-018-0444-y. Epub 2018 Jun 18.

Roman A, Meftah S, Arthaud S, Luppi PH, Peyron C. The inappropriate occurrence of REM sleep in narcolepsy is not due to a defect in homeostatic regulation of REM sleep. SLEEP 2018, 41(6). doi: 10.1093/sleep/zsy046.

Courchet V, Roberts AJ, Meyer-Dilhet G, Del Carmine P, Lewis TL, Polleux F, Courchet J : Haploinsufficiency of autism candidate gene NUAK1 impairs cortical development and behavior. Nature communications (2018) 4289. https://doi.org/10.1038/s41467-018-06584-5

The Ectodysplasin receptor EDAR acts as a tumor suppressor in melanoma by conditionally inducing cell death.Vial J, Royet A, Cassier P, Tortereau A, Dinvaut S, Maillet D, Gratadou-Hupon L, Creveaux M, Sadier A, Tondeur G, Léon S, Depaepe L, Pantalacci S, de la Fouchardière A, Micheau O, Dalle S, Laudet V, Mehlen P, Castets M.Cell Death Differ. 2019 Mar;26(3):443-454. doi: 10.1038/s41418-018-0128-1.

The dependence receptor TrkC regulates the number of sensory neurons during DRG development.Ménard M, Costechareyre C, Coelho-Aguiar JM, Jarrosson-Wuilleme L, Rama N, Blachier J, Kindbeiter K, Bozon M, Cabrera JR, Dupin E, Le Douarin N, Mehlen P, Tauszig-Delamasure S. Dev Biol. 2018 Oct 15;442(2):249-261. doi: 10.1016/j.ydbio.2018.07.022.

Transcriptional regulation of CRMP5 controls neurite outgrowth through Sox5.Cell Mol Life Sci.Naudet N^1,2, Moutal A^1,2, Vu HN^1,2, Chounlamountri N^1,2, Watrin C^1,2, Cavagna S^3,4, Malleval C^1,2, Benetollo C^3,2, Bardel C^2,4,5, Dronne MA^2,4, Honnorat J^1,2,6, Meissirel C², Besançon R^7,8,92018 Jan;75(1):67-79. doi: 10.1007/s00018-017-2634-6. Epub 2017 Sep 1.

Goehrig D, Nigri J, Samain R, Wu Z, Cappello P, Gabiane G, Zhang X, Zhao Y, Kim IS, Chanal M, Curto R, Hervieu V, de La Fouchardière C, Novelli F, Milani P, Tomasini R, Bousquet C, Bertolino P, Hennino A. Stromal protein βig-h3 reprogrammes tumour microenvironment in pancreatic cancer. Gut. 2018 Nov 10

Principe M, Chanal M, Karam V, Wierinckx A, Mikaélian I, Gadet R, Auger C, Raverot V, Jouanneau E, Vasiljevic A, Hennino A, Raverot G, Bertolino P. ALK7 expression in prolactinoma is associated with reduced prolactin and increased proliferation.Endocr Relat Cancer. 2018 Sep;25(9):795-806

Bonnavion R, Teinturier R, Jaafar R, Ripoche D, Leteurtre E, Chen YJ, Rehfeld JF, Lepinasse F, Hervieu V, Pattou F, Vantyghem MC, Scoazec JY, Bertolino P, Zhang CX. Islet Cells Serve as Cells of Origin of Pancreatic Gastrin-Positive Endocrine Tumors. Mol Cell Biol. 2015 Oct;35(19):3274-83.

Patry M, Teinturier R, Goehrig D, Zetu C, Ripoche D, Kim IS, Hennino A, Bertolino P. βig-h3 Represses T-Cell Activation in Type 1 Diabetes. Diabetes. 2015 Dec;64(12):4212-9.

Juban G, Saclier M, Yacoub-Youssef H, Kernou A, Arnold L, Boisson C, Ben Larbi S, Magnan M, Cuvellier S, Théret M, Petrof BJ, Desguerre I, Gondin J, Mounier R, Chazaud B. AMPK Activation Regulates LTBP4-Dependent TGF-β1 Secretion by Pro-inflammatory Macrophages and Controls Fibrosis in Duchenne Muscular Dystrophy. Cell Rep. 2018 Nov 20;25(8):2163-2176.

Le Moal E, Juban G, Bernard AS, Varga T, Policar C, Chazaud B, Mounier R. Macrophage-derived superoxide production and antioxidant response following skeletal muscle injury. Free Radic Biol Med. 2018 May 20;120:33-40.

Tirone M, Tran NL, Ceriotti C, Gorzanelli A, Canepari M, Bottinelli R, Raucci A, Di Maggio S, Santiago C, Mellado M, Saclier M, François S, Careccia G, He M, De Marchis F, Conti V, Ben Larbi S, Cuvellier S, Casalgrandi M, Preti A, Chazaud B, Al-Abed Y, Messina G, Sitia G, Brunelli S, Bianchi ME, Vénéreau E. High mobility group box 1 orchestrates tissue regeneration via CXCR4. J Exp Med. 2018 Jan 2;215(1):303-318.

Ménard M, Costechareyre C, Coelho-Aguiar JM, Jarrosson-Wuilleme L, Rama N, Blachier J, Kindbeiter K, Bozon M, Cabrera JR, Dupin E, Le Douarin N, Mehlen P, Tauszig-Delamasure S. The dependence receptor TrkC regulates the number of sensory neurons during DRG development. Developmental Biology. 2018 Jul 31. pii: S0012-1606(18)30408-1. (2018)

DELLIAUX C, TIAN V. Tian, BOUCHET M, FRADET A, VANPOUILLE N, FLOURENS A, DEPLUS R, VILLERS A, LEROY X, CLEZARDIN P, de LAUNOIT Y, BONNELYE E, DUTERQUE-COQUILLAUD M. TMPRSS2:ERG gene fusion expression regulates bone markers and enhances the osteoblastic phenotype of prostate cancer bone metastases. Cancer Lett. 2018 Dec 1;438:32-43. doi: 10.1016/j.canlet.2018.08.027.

VARGAS G, BOUCHET M, BOUAZZA L, REBOUL P, BOYAULT C, GERVAIS M, KAN C, BENETOLLO C, BREVET M, CROSET M, MAZEL M, CAYREFOURCQ L, GERACI S, VACHER S, PANTANO F, FILIPITS M, DRIOUCH K, BIECH I, GNANT M, JACOT W, AUBIN J.E, DUTERQUE-COQUILLAUD M, ALIX-PANABIERES C, CLEZARDIN P and BONNELYE E. ERRa promotes breast cancer cell dissemination to bone by increasing RANK expression in primary breast tumors. Oncogene, 2018 Nov 26. doi: 10.1038/s41388-018-0579-3.

De Vadder F, Mithieux G. (2018) Gut-brain signaling in energy homeostasis: the unexpected role of microbiota-derived succinate. Journal of Endocrinology, 236: R105-R108.

Gjorgjieva M, Monteillet L, Calderaro J, Mithieux G & Rajas F. (2018) Polycystic kidney features of the renal pathology in glycogen storage disease type 1: possible evolution to renal neoplasia. Journal of Inherited Metabolic Disease, 41:955-963.

Gjorgjieva M, Calderaro J, Monteillet L, Silva M, Raffin M, Brevet M, Romestaing C, Roussel D, Zucman-Rossi J, Mithieux G & Rajas F. (2018) Dietary exacerbation of metabolic stress leads to accelerated hepatic carcinogenesis in glycogen storage disease type Ia. J Hepatol, 69:1074-1087.

Kaneko K, Soty M, Zitoun C, Duchampt A, Silva M, Philippe E, Gautier-Stein A, Rajas F & Mithieux G. (2018) The role of kidney in the inter-organ coordination of endogenous glucose production during fasting. Mol Metab, in press.

Mithieux G . (2018) Does Akkermansia muciniphila play a role in type 1 diabetes? Gut, 67:1373-1374.

Mithieux G. (2018) Gut nutrient sensing and microbiota function in the control of energy homeostasis. Curr Opin Clin Nutr Metab Care, 21:273-276.

Mithieux G. (2018) Gut Microbiota and Host Metabolism: What Relationship. Neuroendocrinology, 106:352-356.

Monteillet L, Gjorgjieva M, Silva M, Verzieux V, Imikirene L, Duchampt A, Guillou H, Mithieux G & Rajas F. (2018). Intracellular lipids are an independent cause of liver injury and chronic kidney disease in non alcoholic fatty liver disease-like context. Mol Metab, In press.

Rosier M, Le Barillier L, Meunier D, El Yacoubi M, Malleret G, Salin PA. Post−learning paradoxical sleep deprivation impairs reorganization of limbic and cortical networks associated with consolidation of remote contextual fear memory in mice. Sleep. 2018. [Epub ahead of print]

2017

Acinar-to-Ductal Metaplasia Induced by Transforming Growth Factor Beta Facilitates KRAS_G12D-driven Pancreatic Tumorigenesis. Chuvin N, Vincent DF, Pommier RM, Alcaraz LB, Gout J, Caligaris C, Yacoub K, Cardot V, Roger E, Kaniewski B, Martel S, Cintas C, Goddard-Léon S, Colombe A, Valantin J, Gadot N, Servoz E, Morton J, Goddard I, Couvelard A, Rebours V, Guillermet J, Sansom OJ, Treilleux I, Valcourt U, Sentis S, Dubus P, Bartholin L. Cell Mol Gastroenterol Hepatol. 2017 May 31;4(2):263-282.

Genetic specification of left-right asymmetry in the diaphragm muscles and their motor innervation. Charoy C, Dinvaut S, Chaix Y, Morlé L, Sanyas I, Bozon M, Kindbeiter K, Durand B, Skidmore JM, De Groef L, Seki M, Moons L, Ruhrberg C, Martin JF, Martin DM, Falk J, Castellani V. Elife. 2017 Jun 22;6. pii: e18481. doi: 10.7554/eLife.18481.

Non-canonical NOTCH3 signalling limits tumour angiogenesis.Lin S, Negulescu A, Bulusu S, Gibert B, Delcros JG, Ducarouge B, Rama N, Gadot N, Treilleux I, Saintigny P, Meurette O, Mehlen P. Nat Commun. 2017 Jul 18;8:16074. doi: 10.1038/ncomms16074.

Floor-plate-derived netrin-1 is dispensable for commissural axon guidance.Dominici C, Moreno-Bravo JA, Puiggros SR, Rappeneau Q, Rama N, Vieugue P, Bernet A, Mehlen P, Chédotal A.Nature. 2017 May 18;545(7654):350-354. doi: 10.1038/nature22331.

Benon A, Ya C, Martin L, Watrin C, Chounlamountri N, Jaaoini I, Honnorat J, Pellier-Monnin V, Noraz N. The Syk kinases orchestrate cerebellar granule cell tangential migration. Neuroscience. 2017 Sep 30;360:230-239. PMID: 28768156

Gherardi S, Ripoche D, Mikaelian I, Chanal M, Teinturier R, Goehrig D, Cordier-Bussat M, Zhang CX, Hennino A, Bertolino P. Menin regulates Inhbb expression through an Akt/Ezh2-mediated H3K27 histone modification. Biochim Biophys Acta. 2017 Apr;1860(4):427-437

Latroche C, Weiss-Gayet M, Muller L, Gitiaux C, Leblanc P, Liot S, Ben-Larbi S, Abou-Khalil R, Verger N, Bardot P, Magnan M, Chrétien F, Mounier R, Germain S, Chazaud B. Coupling between Myogenesis and Angiogenesis during Skeletal Muscle Regeneration Is Stimulated by Restorative Macrophages. Stem Cell Reports. 2017 Dec 12;9(6):2018-2033.

Theret M, Gsaier L, Schaffer B, Juban G, Ben Larbi S, Weiss-Gayet M, Bultot L, Collodet C, Foretz M, Desplanches D, Sanz P, Zang Z, Yang L, Vial G, Viollet B, Sakamoto K, Brunet A, Chazaud B, Mounier R. AMPKα1-LDH pathway regulates muscle stem cell self-renewal by controlling metabolic homeostasis. EMBO J. 2017 Jul 3;36(13):1946-1962.

Barataud A, Goncalves D, Vinera J, Zitoun C, Duchampt A, Gautier-Stein A & Mithieux G. (2017) Absence of role of dietary protein sensing in the metabolic benefits of duodenal-jejunal bypass in the mouse. Scientific Reports, 23:44856.

Hijmans BS, Boss A, van Dijk TH, Soty M, Wolters H, Mutel E, Groen AK, Derks TGJ, Mithieux G, Heerschap A, Reijngoud DJ, Rajas F, Oosterveer MH (2017) Hepatocytes contribute to residual glucose production in a mouse model for glycogen storage disease type Ia. Hepatology, 66: 2042-2054.

Mithieux G. (2017) Gut microbiota and host metabolism: what relationship ? Neuroendocrinology, 106:352-356.

Mithieux G, Rajas F, Gautier-Stein A & Soty M. (2018) Adaptation of hepatic, renal and intestinal gluconeogenesis during food deprivation. Handbook of Famine, Starvation, and Nutrient Deprivation. Springer International Publishing AG 2017.

Soty M, Gautier-Stein A, Rajas F & Mithieux G. (2017) Gut-brain glucose signaling in energy homeostasis. Cell Metab, 25:1231-1242.

Weis S, Carlos AR, Moita MR, Singh S, Blankenhaus B, Cardoso S, Larsen R, Rebelo S, Schäuble S, Del Barrio L, Mithieux G, Rajas F, Lindig S, Bauer M, Soares MP. (2017) Metabolic Adaptation Establishes Disease Tolerance to Sepsis.Cell, 169:1263-1275.

Machado NJ, Simões AP, Silva HB, Ardais AP, Kaster MP, Garção P,Rodrigues DI, Pochmann D, Santos AI, Araújo IM,Porciúncula LO, Tomé ÂR, Köfalvi A, Vaugeois JM, Agostinho P, El Yacoubi M, Cunha RA, Gomes CA. Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses. Mol Neurobiol. 2017. 54:1552-1563

2016

Netrin-1 Interrupts Amyloid-β Amplification, Increases sAβPPα in vitro and in vivo, and Improves Cognition in a Mouse Model of Alzheimer's Disease.Spilman PR, Corset V, Gorostiza O, Poksay KS, Galvan V, Zhang J, Rao R, Peters-Libeu C, Vincelette J, McGeehan A, Dvorak-Ewell M, Beyer J, Campagna J, Bankiewicz K, Mehlen P, John V, Bredesen DE.J Alzheimers Dis. 2016 Mar 8;52(1):223-42. doi: 10.3233/JAD-151046.

Targeting netrin-1/DCC interaction in diffuse large B-cell and mantle cell lymphomas.Broutier L, Creveaux M, Vial J, Tortereau A, Delcros JG, Chazot G, McCarron MJ, Léon S, Pangault C, Gadot N, Colombe A, Boulland ML, Blachier J, Marie JC, Traverse-Glehen A, Donzé O, Chassagne-Clément C, Salles G, Tarte K, Mehlen P, Castets M.EMBO Mol Med. 2016 Feb 1;8(2):96-104. doi: 10.15252/emmm.201505480.

Noraz N, Jaaoini I, Charoy C, Watrin C, Chounlamountri N, Benon A, Malleval C, Boudin H, Honnorat J, Castellani V, Pellier-Monnin V. Syk kinases are required for spinal commissural axon repulsion at the midline via the ephrin/Eph pathway. Development. 2016, 143(12):2183-93. PMID: 27122172

Ripoche D, Charbord J, Hennino A, Teinturier R, Bonnavion R, Jaafar R, Goehrig D,Cordier-Bussat M, Ritvos O, Zhang CX, Andersson O, Bertolino P. ActivinB is inuced in Insulinoma to promote tumor plasticity through a β-cell induced dedifferentiation. Mol Cell Biol. 2016 March: 756-764

Varga T, Mounier R, Horvath A, Cuvellier S, Dumont F, Poliska S, Ardjoune H, Juban G, Nagy L, Chazaud B. Highly Dynamic Transcriptional Signature of Distinct Macrophage Subsets during Sterile Inflammation, Resolution, and Tissue Repair. J Immunol. 2016 Jun 1;196(11):4771-82.

M BOUCHET^*, A FRADET^*, C DELLIAUX, M GERVAIS, C KAN, C BENETOLLO, F PANTANO, G VARGAS, L BOUAZZA, M CROSET, Y BALA, X LEROY, TJ ROSOL , J RIEUSSET, A BELLAHCENE, V CASTRONOVO, JE AUBIN_,P CLEZARDIN, M DUTERQUE-COQUILLAUD, E BONNELYE. Estrogen related receptor alpha in castration-resistant prostate cancer cells promotes tumor progression in bone. Oncotarget, 2016 Nov 22;7(47):77071-77086. doi: 10.18632/oncotarget.12787.

Casteras S, Abdul-Wahed A, Soty M, Vulin F, Guillou H, Campana M, Le Stunff H, Pirola L, Rajas F, Mithieux G & Gautier-Stein A. (2016) The suppression of hepatic glucose production improves metabolism and insulin sensitivity in subcutaneous adipose tissue in mice. Diabetologia, 59: 2645-2653.

De Vadder F, Kovatcheva-Datchary P, Zitoun C, Duchampt A, Bäckhed F & Mithieux G (2016) Microbiota-produced succinate improves glucose homeostasis via intestinal gluconeogenesis. Cell Metab, 24: 151-157.

Gautier-Stein A & Mithieux G (2016) Le Point Sur: L’axe intestin-cerveau en santé métabolique. Nutrition & Endocrinologie, 14: 58-61.

Gjorgjieva M, Raffin M, Duchampt A, Perry A, Stefanutti A, Brevet M, Tortereau A, Dubourg L, Hubert-Buron A, Mabille M, Pelissou C, Lassalle L, Labrune P, Mithieux G & Rajas F. (2016) Progressive development of renal cysts in glycogen storage disease type 1. Hum Mol Genet, 25: 3784-3797.

Lee YS, De Vadder F, Tremaroli V, Wichmann, Mithieux G & Bäckhed F (2016) Insulin-like peptide 5 is a microbiolly regulated peptide that promotes hepatic gluconeogenesis. Mol Metab, 5: 263-270.

Montagner A, Korecka A, Polizzi A, Lippi Y, Blum Y, Canlet C, Tremblay-Franco M, Gautier-Stein A, Burcelin R, Yen YC, Je HS, Maha AA, Mithieux G, Arulampalam V, Lagarrigue S, Guillou H, Pettersson S & Wahli W. (2016) Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals. Sci Rep, 6: 20127.

Soty M, Chilloux J, Delalande F, Zitoun C, Bertile F, Mithieux G & Gautier-Stein A (2016) Post-translational regulation of the glucose-6-phosphoatase complex by cyclicadenosine monophosphate is a crucial determinant of endogenous glucose production and is controlled by the glucose-6-phosphate transporter”. J Proteome Res, 15: 1342-1349.

Soty M, Chilloux J, Delalande F, Zitoun C, Bertile F, Mithieux G & Gautier-Stein A (2016) Correction to “Post-translational regulation of the glucose-6-phosphoatase complex by cyclicadenosine monophosphate is a crucial determinant of endogenous glucose production and is controlled by the glucose-6-phosphate transporter”. J Proteome Res, 15: 1734.

2015

TIF1γ Suppresses Tumor Progression by Regulating Mitotic Checkpoints and Chromosomal Stability. Pommier RM, Gout J, Vincent DF, Alcaraz LB, Chuvin N, Arfi V, Martel S, Kaniewski B, Devailly G, Fourel G, Bernard P, Moyret-Lalle C, Ansieau S, Puisieux A, Valcourt U, Sentis S, Bartholin L.
Cancer Res. 2015 Oct 15;75(20):4335-50. doi: 10.1158/0008-5472.CAN-14-3426. Epub 2015 Aug 17.PMID:26282171

Cerebrospinal fluid-derived Semaphorin3B orients neuroepithelial cell divisions in the apicobasal axis. Arbeille E, Reynaud F, Sanyas I, Bozon M, Kindbeiter K, Causeret F, Pierani A, Falk J, Moret F, Castellani V. Nat Commun. 2015 Feb 27;6:6366. doi: 10.1038/ncomms7366.

PlexinA1 is a new Slit receptor and mediates axon guidance function of Slit C-terminal fragments.
Delloye-Bourgeois C, Jacquier A, Charoy C, Reynaud F, Nawabi H, Thoinet K, Kindbeiter K, Yoshida Y, Zagar Y, Kong Y, Jones YE, Falk J, Chédotal A, Castellani V. Nat Neurosci. 2015 Jan;18(1):36-45. doi: 10.1038/nn.3893. Epub 2014 Dec 8.

Arthaud S, Varin C, Gay N, Libourel PA, Fort P, Luppi PH, Peyron C. Paradoxical (REM) Sleep Deprivation and rebound in mice: Polygraphic recordings and Hypothalamic Neuronal Activation. J Sleep Res. 2015, 24(3):309-319.

Netrin-1 regulates somatic cell reprogramming and pluripotency maintenance.Ozmadenci D, Féraud O, Markossian S, Kress E, Ducarouge B, Gibert B, Ge J, Durand I, Gadot N, Plateroti M, Bennaceur-Griscelli A, Scoazec JY, Gil J, Deng H, Bernet A, Mehlen P, Lavial F. Nat Commun. 2015 Jul 8;6:7398. doi: 10.1038/ncomms8398.

Kistler WS, Baas D, Lemeille S, Paschaki M, Seguin-Estevez Q, Barras E, Ma W, Duteyrat JL, Morlé L, Durand B, Reith W. RFX2 Is a Major Transcriptional Regulator of Spermiogenesis. PLoS Genet. (2015) 11:e1005368. doi: 10.1371/journal.pgen.1005368.

The ciliogenic transcription factor Rfx3 is required for the formation of the thalamocortical tract by regulating the patterning of prethalamus and ventral telencephalon.
Magnani D, Morlé L, Hasenpusch-Theil K, Paschaki M, Jacoby M, Schurmans S, Durand B, Theil T.
Hum Mol Genet. 2015 May 1;24(9):2578-93. doi: 10.1093/hmg/ddv021. Epub 2015 Jan 28.

Chan KL, Pillon NJ, Sivaloganathan DM, Costford SR, Liu Z, Théret M, Chazaud B, Klip A. Palmitoleate Reverses High Fat-induced Proinflammatory Macrophage Polarization via AMP-activated Protein Kinase (AMPK). J Biol Chem. 2015 Jul 3;290(27):16979-88.

Gondin J, Théret M, Duhamel G, Pegan K, Mathieu JR, Peyssonnaux C, Cuvellier S, Latroche C, Chazaud B, Bendahan D, Mounier R. Myeloid HIFs are dispensable for resolution of inflammation during skeletal muscle regeneration. J Immunol. 2015 Apr 1;194(7):3389-99.

Clar J, Mutel E, Gri B, Creneguy A, Stefanutti A, Gaillard S, Ferry N, Beuf O, Mithieux G, Nguyen TH & Rajas F. (2015) Hepatic lentiviral transfer prevents the long-term onset of hepatic tumours of glycogen storage disease type 1a in mice. Hum Mol Genet, 24: 2287-2296.

De Vadder F & Mithieux G. (2015) Contrôle de la glycémie par l'axe nerveux intestin-cerveau. Medecine/Sciences, 31: 168-173.

De Vadder F, Plessier F, Gautier-Stein A & Mithieux G. (2015) Vasoactive intestinal peptide is a local mediator in a gut-brain neural axis activating intestinal gluconeogenesis. Neurogastroenterology and Motility, 27: 443-448.

Goncalves D, Barataud A, De Vadder F, Vinera J, Zitoun C, Duchampt A & Mithieux G. (2015) Bile routing modification reproduces key features of gastric bypass in rat. Ann Surg, 262: 1006-1015.

Rajas F, Clar J, Gautier-Stein A & Mithieux G. (2015) Lessons from new mouse models of glycogen storage disease type 1a in relation to the time course and organ specificity of the disease. Journal of Inherited Metabolic Disease, 38: 521-527.

Soty M, Penhoat A, Amigo-Correig M, Vinera J, Sardella A, Vullin-Bouilloux F, Zitoun C, Houberdon I & Mithieux G. (2015) A gut-brain neural circuit controlled by intestinal gluconeogenesis is crucial in metabolic health, Molecular Metabolism, 26: 106-117.

Sahay D, Leblanc R, Grunewald TG, Ambatipudi S, Ribeiro J, Clézardin P, Peyruchaud O. (2015). The LPA1/ZEB1/miR-21-activation pathway regulates metastasis in basal breast cancer. Oncotarget. 6(24):20604-20. IF: 5.1

Rappeneau V, Morel AL, El Yacoubi M, Vaugeois JM, Denoroy L, Bérod A. Enhanced cocaine-associated contextual learning in female H/Rouen mice selectively bred for depressive-like behaviors: molecular and neuronal correlates. Int J Neuropsychopharmacol. 2015.18: pii: pyv022. doi: 10.1093/ijnp/pyv022.

2014

O'Leary OF, Felice D, Galimberti S, Savignac HM, Bravo JA, Crowley T, El Yacoubi M, Vaugeois JM, Gassmann M, Bettler B, Dinan TG, Cryan JF.GABAB(1) receptor subunit isoforms differentially regulate stress resilience. Proc Natl Acad Sci U S A.2014, 111:15232-15237.

Targeted deletion of kidney glucose-6 phosphatase leads to nephropathy. Julie Clar1,2,3, Blandine Gri1,2,3, Julien Calderaro4, Marie-Christine Birling5, Yann He´rault5, G. Peter A. Smit6, Gilles Mithieux1,2,3 and Fabienne Rajas1,2,3

Leblanc R, Lee SC, David M, Bordet JC, Norman DD, Patil R, Miller D, Sahay D, Ribeiro J, Clézardin P, Tigyi GJ, Peyruchaud O. (2014) Interaction of platelet-derived autotaxin with tumor integrin αVβ3 controls metastasis of breast cancer cells to bone. Blood. 124 (20): 3141-3150

David M, Sahay D, Mege F, Descotes F, Leblanc R, Ribeiro J, Clézardin P and Peyruchaud O. (2014) Identification of heparin-binding EGF-like growth factor (HB-EGF) as a biomarker for lysophosphatidic acid receptor type 1 (LPA1) activation in human breast and prostate cancers. PLoS One. 14;9(5):e97771.

Bachelier R, Confavreux C, Peyruchaud O, Croset M, Goerhig D, van der Pluijm and Clézardin P. (2014) Combination of Antiangiogenic Therapies Reduces Osteolysis and Tumor Burden in Experimental Breast Cancer Bone Metastasis. International Journal of cancer. 135(6):1319-29.

David M, Machuca-Gayet I, Kikuta J,Ottewell P,Mima F, Leblanc, Bonnelye E, Ribeiro J, Holen I, Lopez Vales R, Jurdic P, Chun J, Clézardin P, Ishii M and Peyruchaud O. 2014 _ Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity. Journal of Biological Chemistry. 289 (10): 6551-64.

Abdul-Wahed A, Gautier-Stein A, Casteras S, Soty M, Roussel D, Romestaing C, Guillou H, Tourette JA, Pleche N, Zitoun C, Gri B, Sardella A, Rajas F & Mithieux G. (2014) A link between hepatic glucose production and peripheral energy metabolism via hepatokines. Molecular Metabolism, 3: 531-543.

Clar J, Gri B, Calderaro J, Birlong MC, Hérault Y, Smith GPA, Mithieux G & Rajas F. (2014) Targeted deletion of glucose-6 phosphatase leads to nephropathy. Kidney International, 86: 747-756.

De Vadder F, Kovatcheva-Datchary P, Goncalves D, Vinera J, Zitoun C, Duchampt A, Backhed F & Mithieux G. (2014) Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits. Cell, 156: 84-96.

Mithieux G. (2014) Nutropioids regulate gut-brain circuitry controlling food intake. Front Horm Res, 42: 155-162.

Mithieux G. (2014) Nutrient Control of Energy Homeostasis Via Gut-Brain Neural Circuits. Neuroendocrinology, 100: 89-94.

Mithieux G. (2014) Metabolic effects of portal vein sensing. Diabetes Obes Metab, 16: Suppl 1 56-60.

Mithieux G & Gautier-Stein A. (2014) Intestinal glucose metabolism revisited. Diabetes Res Clin Pract, 105: 295-301.

Penhoat A, Fayard L, Stefanutti A, Mithieux G & Rajas F. (2014) Intestinal gluconeogenesis is crucial to maintain a physiological fasting glycemia in the absence of hepatic glucose production in mice. Metabolism, 63: 104-111.

2013

Hesling C, Lopez J, Fattet L, Gonzalo P, Treilleux I, Blanchard D, Losson R, Goffin V, Pigat N, Puisieux A, Mikaelian I, Gillet G, Rimokh R. Tif1γ is essential for the terminal differentiation of mammary alveolar epithelial cells and for lactation through SMAD4 inhibition. Development. 2013 Jan 1;140(1):167-75

Intestinal gluconeogenesis is crucial to maintain a physiological fasting glycemia in the absence of hepatic glucose production in mice. Penhoat A, Fayard L, Stefanutti A, Mithieux G, Rajas F.Institut National de la Santé et de la Recherche Médicale, U855, Lyon 69372, France; University of Lyon, Lyon 69008, France; University Lyon 1, Villeurbanne 69622, France. Metabolism. 2013 Oct 14. pii: S0026-0495(13)00289-8

Christelle Seigne, Magdalena Auret, Isabelle Treilleux, Rémy Bonnavion, Fouzia Assade, Christine Carreira, Sophie Goddard-Léon, Emilie Lavergne, Sylvie Chabaud, Amandine Garcia, Sylvie Mazoyer, Jieli Lu, Thomas Bachelot, Lucien Frappart and Chang Xian Zhang. High incidence of mammary intraepithelial neoplasia development in Men1-disrupted murine mammary glands. J Pathology 229: 546-558, 2013.

Rémy Bonnavion, Rami Jaafar, Julie Kerr-Conte, Fouzia Assade, Esther van Stralen, Emmanuelle Leteurtre, Célio Pouponnot, Sofia Gargani, François Pattou, Philippe Bertolino, Martine Cordier-Bussat, Jieli Lu, Chang Xian Zhang. Both PAX4 and MAFA Are Expressed in a Substantial Proportion of Normal Human Pancreatic Alpha Cells and Deregulated in Patients with Type 2 Diabetes. PlosOne, 8(8):e72194. 2013.

2012

Mu-opioid receptors and dietary protein stimulate a gut-brain neural circuitry limiting food intake.Duraffourd C, De Vadder F, Goncalves D, Delaere F, Penhoat A, Brusset B, Rajas F, Chassard D, Duchampt A, Stefanutti A, Gautier-Stein A, Mithieux G. Cell. 2012 Jul 20;150(2):377-88. doi: 10.1016/j.cell.2012.05.039. Epub 2012 Jul 5.

Doriane Ripoche, Johann Gout, Roxane M. Pommier, Rami Jaafar, Chang X. Zhang, Laurent Bartholin and Philippe Bertolino. Generation of a Conditional Mouse Model to Target Acvr1b Disruption in Adult Tissues. Genesis, 51 (2), 120-127, 2012

J Lu, Z Hamze, R Bonnavion, N Herath, C Pouponnot, F Assade, S Fontanie`re, P Bertolino, M Cordier-Bussat and CX Zhang. Reexpression of oncoprotein MafB in proliferative b-cells and Men1 insulinomas in mouse. Oncogene 31: 3647-3654. 2012.

2011

Starck J, Weiss-Gayet M, Gonnet C, Guyot B, Vicat JM, Morlé F. Inducible Fli-1 gene deletion in adult mice modifies several myeloid lineage commitment decisions and accelerates proliferation arrest and terminal erythrocytic differentiation. Blood. 2010 Dec 2;116(23):4795-805.

Physiol Behav. 2011 Nov 30;105(1):89-93. doi: 10.1016/j.physbeh.2011.03.012. Epub 2011 Mar 21.Protein-induced satiety is abolished in the absence of intestinal gluconeogenesis. Penhoat A, Mutel E, Amigo-Correig M, Pillot B, Stefanutti A, Rajas F, Mithieux G.

J Hepatol. 2011 Mar;54(3):529-37. doi: 10.1016/j.jhep.2010.08.014. Epub 2010 Oct 1.Targeted deletion of liver glucose-6 phosphatase mimics glycogen storage disease type 1a including development of multiple adenomas.Mutel E, Abdul-Wahed A, Ramamonjisoa N, Stefanutti A, Houberdon I, Cavassila S, Pilleul F, Beuf O, Gautier-Stein A, Penhoat A, Mithieux G, Rajas F.

Diabetes. 2011 Dec;60(12):3121-31. doi: 10.2337/db11-0571. Epub 2011 Oct 19.Control of blood glucose in the absence of hepatic glucose production during prolonged fasting in mice: induction of renal and intestinal gluconeogenesis by glucagon.Mutel E, Gautier-Stein A, Abdul-Wahed A, Amigó-Correig M, Zitoun C, Stefanutti A, Houberdon I, Tourette JA, Mithieux G, Rajas F.