SFR Santé Lyon Est

Université Lyon 1 – CNRS UAR 3453 – Inserm US 7

Service Commun des Animaleries de Rockefeller (SCAR)

Visite virtuelle du SCAR

Le Service Commun des Animaleries de Rockefeller (SCAR) est une plateforme de l’Université Claude Bernard Lyon 1 rattachée à SFR Santé Lyon Est, qui a pour mission d’accueillir des animaux (rats et souris) en vue de projets de recherche scientifique et d’activités d’enseignement. Les projets innovants sont réalisés par des équipes de recherche publiques ainsi que des structures privées.

Nous travaillons dans divers domaines d’activité tels que :

  • La recherche fondamentale (études intégratives sur des animaux vigiles ou anesthésiés et sur des prélèvements d’origine animale) ;
  • Des essais sur animaux d’efficacité ou d’innocuité de médicaments et différents principes actifs ;
  • Des explorations fonctionnelles chez l’animal de laboratoire ;
  • L’enseignement et des travaux pratiques.

Notre structure de type conventionnel vous offre la possibilité d’héberger des animaux (OGM ou non) dans la limite de notre capacité d’accueil. Les animaux sont hébergés dans les locaux spécifiques pour chaque espèce tout en étant en adéquation avec :

  • La directive 2010/63/UE du Parlement européen et du Conseil du 22 septembre 2010 relative à la protection des animaux utilisés à des fins scientifiques ;
  • Les décret et arrêtés de février 2013.

Nos diverses prestations vont de la mise à disposition de locaux d’infrastructure agréés, avec des espaces dédiés à la stabulation et l’expérimentation sur les modèles couverts par l’agrément, à l’hébergement, l’entretien et la surveillance quotidienne des modèles animaux, en passant par l’élevage de lignée à façon.

Nous effectuons également des expérimentations à façon sous forme de prestations réalisées dans le cadre de votre projet.

N’hésitez pas à nous contacter pour toute demande complémentaire.

Contact

Bibliographie

Voici les derniers articles déclarés pour le SCAR :

6024536 5XTY8I85 1 apa 10 default 200 https://sfrsantelyonest.univ-lyon1.fr/wp-content/plugins/zotpress/
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Fels, E., Mayeur, M.-E., Wayere, E., Vincent, C., Malleval, C., Honnorat, J., & Pascual, O. (2022). Dysregulation of the hippocampal neuronal network by LGI1 auto-antibodies. PLOS ONE, 17(8), e0272277. https://doi.org/10.1371/journal.pone.0272277
Hristovska, I., Robert, M., Combet, K., Honnorat, J., Comte, J.-C., & Pascual, O. (2022). Sleep decreases neuronal activity control of microglial dynamics in mice. Nature Communications, 13(1), 6273. https://doi.org/10.1038/s41467-022-34035-9
Gouez, M., Rébillard, A., Thomas, A., Beaumel, S., Matera, E.-L., Gouraud, E., Orfila, L., Martin, B., Pérol, O., Chaveroux, C., Chirico, E. N., Dumontet, C., Fervers, B., & Pialoux, V. (2024). Combined effects of exercise and immuno-chemotherapy treatments on tumor growth in MC38 colorectal cancer-bearing mice. Frontiers in Immunology, 15, 1368550. https://doi.org/10.3389/fimmu.2024.1368550
Fessard, A., Zavoriti, A., Boyer, N., Guillemaud, J., Rahmati, M., Del Carmine, P., Gobet, C., Chazaud, B., & Gondin, J. (2025). Neuromuscular electrical stimulation training induces myonuclear accretion and hypertrophy in mice without overt signs of muscle damage and regeneration. Skeletal Muscle, 15(1), 3. https://doi.org/10.1186/s13395-024-00372-0