La plateforme Primage a pour mission d’accueillir des primates dans le cadre de recherches utilisant de l’imagerie par résonance magnétique (IRM). Elle propose un hébergement spécifique en adéquation avec la réglementation en vigueur ainsi que des espaces pour la réalisation des projets.
La plateforme bénéficie du cadre d’un établissement agréé et est intégrée dans l’activité de sa structure chargée du bien-être des animaux. Elle bénéficie ainsi des conseils et du suivi de personnels travaillant en permanence avec les macaques (animaliers, vétérinaire, techniciens). En plus de l’hébergement des animaux, Primage vous accompagne aussi dans l’avant, le pendant et l’après-projet et reste en contact avec les animaux même après leur retraite !
La visite virtuelle qui était proposée par le CNRS n’existant plus, une visite de Primage est en cours de réalisation en lien avec le Gircor. Nous vous invitons à revenir prochainement sur cette page pour la découvrir !
Les recherches menées à Primage s’intéressent aux fonctions cognitives complexes propres aux primates. Dans ce cadre, le macaque reste un modèle indispensable. Il est entraîné à réaliser des tâches complexes sur ordinateur dans l’IRM. Ces études permettent de produire un savoir scientifique sur lequel repose notre compréhension des êtres vivants. Ce savoir permet le développement de recherches translationnelles dont le but est de trouver de nouveaux traitements pour des maladies telles que la maladie d’Alzheimer, la maladie de Parkinson, les troubles de l’attention chez l’enfant…
Un exemple de recherche à Primage
Cette image parue dans Nature Communications montre la continuité de l’organisation anatomique des sillons du cerveau médian du macaque à l’Homme.
Amiez, C., Sallet, J., Hopkins, W. D., Meguerditchian, A., Hadj-Bouziane, F., Ben Hamed, S., Wilson, C. R. E., Procyk, E., & Petrides, M. (2019). Sulcal organization in the medial frontal cortex provides insights into primate brain evolution. Nature Communications, 10(1), 1–14.
Les données de neuro-imagerie collectées à Primage sont mises à disposition de la communauté internationale via le site de partage PRIMATE Data Exchange (PRIMatE). Ceci permet à terme de réduire le nombre de macaques dans les instituts de recherche en permettant à d’autres scientifiques d’exploiter des données sans nouvelles expérimentations chez l’animal.
Appareils de biochimie et d’hématologie
La plateforme Primage met à disposition deux appareils de suivi de constantes biologiques nécessaires au suivi sanitaire des PNH mais également très utiles en recherche pour évaluer le bien-être des animaux.
Voici des tableaux récapitulatifs des caractéristiques des deux appareils de la société Melet Schloesing Laboratories.
Appareil de biochimie
| Plaquette de l’appareil et documentation | Plaquette de présentation Procédure d’utilisation Manuel utilisateur |
|---|---|
| Image |  |
| Technologie | Chimie sèche |
| Mobile | Oui (19 x 22 x 21 cm) |
| Analyses réalisées | 37 paramètres dans des bilans. TESTS : Albumine, phosphatase alcaline, Alanine transférase, amylase, aspartate aminotransférase, urée, calcium, cholinestérase, chlore, créatine kinase, créatinine, fructosamine, glucose, gamma GT, potassium, lactate, lactate déshydrogénase, lipase, magnésium, sodium, phosphore, bilirubine totale, acides biliaires, cholestérol total, bicarbonates, Triglycérides, protéine totale, acide urique, protéine sérique amyloïde A, protéine C-réactive, thromboplastine partielle activée, fibrinogène, prothrombine, temps de prothrombine, albumine/globuline, urée/créatinine, globuline. BILANS : Grand bilan, perfect 13, test complet, bilan de santé, préopératoire, diabète, fonction hépatique, fonction rénale, électrolytes, inflammation féline, inflammation canine, coagulation. + Fleks 2 (rotor à personnaliser avec 2 tests à choisir parmi 9) + Fleks 6 (rotor à personnaliser avec 6 tests à choisir parmi 23) |
| Volume de sang nécessaire | 90-120 µL (dépend du rotor) |
| Volume d’échantillon prélevé | 90-120 µL (dépend du rotor) |
| Type d’échantillon | Sang total, sérum ou plasma prélevé sur héparine lithium (tubes de 1 mL disponibles sur la boutique de MS Labo) |
| Temps d’analyse | 12 minutes par échantillon |
| Export des données | Impression ou ticket |
| Dépôt prélèvement de l’échantillon | Dépôt via une micropipette |
| Formation | 10 minutes |
| Consommables/réactifs à prévoir | Tubes de prélèvement (d’autres références que celle de MS Labo peuvent être utilisés) Rotor de tests |
| En cas de problème | Le contact du SAV est affiché sur l’appareil. |
Appareil d’hématologie
| Plaquette de l’appareil et documentation | Plaquette de présentation Procédure d’utilisation Manuel utilisateur Calendrier de maintenance Procédure d’export des données |
|---|---|
| Image |  |
| Technologie | Impédance électronique |
| Mobile | Non (ou via la boîte de transport et avec procédure spéciale : contacter le SAV) |
| Analyses réalisées | GB, Lym, Mon, Neu, Eos, Ba (valeur absolue et %), GR, HB, VGM, Hct, TCMH, CCMH, IDR-CV, IDR-SD, Plt, VMP, Pct, IDP, µ-GR, macro-GR, Mode, médiane, µ-THR%, macro-THR%. |
| Volume de sang nécessaire | 100 µL |
| Volume d’échantillon prélevé | 40 µL (3 populations) – 80 µL (5 populations) |
| Type d’échantillon | Sang total prélevé sur EDTA K3 (tubes de 1,3 mL disponibles sur la boutique de MS Labo) |
| Temps d’analyse | 60-90 secondes |
| Export des données | Impression ou CD-ROM (à prévoir) |
| Dépôt prélèvement de l’échantillon | Aspiration directement dans le tube par l’appareil via une seringue intégrée |
| Formation | 30 minutes |
| Consommables/réactifs à prévoir | Tubes de prélèvement (d’autres références que celle de MS Labo peuvent être utilisés) Pack réactif 250 tests Tube de sang contrôle qualité Filtres |
| Autre | Banque de données : lapin, chat, PNH, souris, rat, porc et autres paramétrables (contacter le SAV) |
| En cas de problème | Le contact du SAV est affiché sur l’appareil. |
Au préalable des commandes des réactifs, tests consommables :
Si votre équipe possède déjà un compte chez MS Labo et un espace utilisateur sur la boutique, utilisez-le afin de faire votre panier qui sera la base de votre bon de commande (BC). Générer votre BC via les procédures d’achat de votre établissement. Récupérer le numéro de BC afin de finaliser votre commande sur la boutique MS labo (faire figurer le numéro de bon de commande interne dans les instructions de la commande boutique en ligne « Case commentaire »). Si vous avez des commandes récurrentes, un bon prévisionnel (via les procédures d’achat de votre établissement) peut être réalisé, ainsi il suffit de passer les commandes sur la boutique en ligne jusqu’à épuisement du bon prévisionnel.
Si votre équipe ne dispose pas de numéro de client, envoyer un mail à commercial@mslabos.com en fournissant l’adresse de facturation et l’adresse de livraison ainsi que le n° de série de l’appareil. Un devis sera rédigé et vous sera envoyé par e-mail directement avec les mentions nécessaires. Vous aurez alors par la suite un numéro de client.
N’hésitez pas à appeler Madame SAVARY au 01 30 75 30 00 et à l’invite vocale tapez « 1 ».
Pour réserver les appareils et demander une formation : hemato-biochsfrlyon-est@listes.univ-lyon1.fr
Contact
Bibliographie
Voici les derniers articles déclarés pour la plateforme Primage :
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